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Rather than interacting with receptors on the plasma membrane of their target cells, the gasotransmitters (soluble gases such as nitric oxide and carbon monoxide, as unconventional neurotransmitters) can cross the cell membrane and act directly on molecules inside the cell [36]

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This selective targeting strategy represents a precision-based approach to senolysis, focusing on restoring intrinsic apoptosis rather than inducing external stress

10.1074/jbc.M510562200

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